1. Guideline on non-clinical and clinical development of similar biological medicinal products containing low molecular weight heparins. London, 2009. EMEA/CHMP/BMWP/118264/2007.
2. Российские клинические рекомендации по диагностике, лечению и профилактике венозных тромбоэмболических осложнений. Ассоциация флебологов России, Всероссийское общество хирургов. М.: Медиа Сфера, 2010.
3. Geerts WH, Bergqvist D, Pineo GF et al. Prevention of Venous Thromboembolism. American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133: 381S–453S.
4. Kearon C, Kahn SR, Agnelli G et al. Antithrombotic Therapy for Venous Thromboembolic Disease. American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133: 454S–545S.
5. Guidelines o the diagnosis and management of acute pulmonary embolism. The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology. Eur Heart J 2008; 29: 2276–315.
6. Falkon L, Saenz-Campos D, Antonijoan R et al. Bioavailability and pharmacokinetics of a new low molecular weight heparin (RO-11). A three way cross-over study in healthy volunteers. Thromb Res 1995; 78: 77–86.
7. Borrell M, Antonijoan RM, Ortin R et al. Pharmacokinetic profiles of two LMWH: Bemiparin 3,500 IU and Enoxaparin 4,000 IU after subcutaneous administration in healthy volunteers. Thromb Haemost 2001; 86 (Suppl. CD3578).
8. Falkon L, Bayes M, Frontera G et al. Pharmacokinetics and tolerability of a new low molecular mass heparin (RO-11) in healthy volunteers – a dose-finding study within the therapeutical range. Thromb Haemost 1997; 77: 133–6.
9. Collignon F, Frydman A, Caplain H et al. Comparison of the pharmacokinetic profiles of three low molecular mass heparins – dalte-parin, enoxaparin, nadroparin – administered subcutaneously in heathy volunteers (doses for prevention of thromboembolism). Thromb Haemost 1995; 73: 630–40.
10. Eriksson BI, Soderberg K, Widlund L et al. A comparative study of three low-molecular weight heparins (LMWH) and unfractionated heparin (UH) in healthy volunteers. Thromb Haemost 1995; 73: 398–401.
11. Moreno Gonzalez E, Fontcuberta J, De La Llama F. Prophylaxis of thromboembolic disease with RO-11 (ROVI), during abdominal surgery. Hepatogastroenterology 1996; 43: 744–7.
12. Kakkar W, Howes J, Sharma V, Kadziola Z. A comparative, double-blind, randomized trial of a new-second generation LMWH (Bemiparin) and UFH in the prevention of post-operative venous thromboembolism in patients undergoing hip arthroplasty. Thromb Haemost 2000; 83: 523–9.
13. Abad JI, Gomez-Outes A, Martinez-Gonzalez J, Rocha E.
A prospective observational study on the effectiveness and safety of bemiparin, first dose administered 6 h after knee or hip replacement surgery. Arch Orthop Trauma Surg 2007; 127 (8): 665–70.
14. Navarro-Quilis A, Castellet E, Rocha E et al. Efficacy and safety of bemiparin compared with Enoxaparin in the prevention of venous thromboembolism after total knee arthroplasty. A randomized double-blind clinical trial. J Thromb Haemost 2003; 1: 425–32.
15. Vavken P, Lunzer A, Grohs JG. A prospective cohort study on the effectiveness of 3500 IU versus 5000 IU bemiparin in the prophylaxis of postoperative thrombotic events in obese patients undergoing orthopedic surgery. Wien Klin Wochenschr 2009; 121 (13–14): 454–8.
16. Rodriguez-Manas L, Gomez-Huelgas R, Veiga-Fernandez F et al. Thromboprophylaxis with the low-molecular-weight heparin bemiparin sodium in elderly medical patients in usual clinical practice: the ANCIANOS study. Clin Drug Investig 2010; 30 (5): 337–45.
17. Balibrea JL, Altimiras J, Larruzea I et al. Optimal dosing of bemiparin as prophylaxis against venous thromboembolism in surgery for cancer: an audit of practice. Int J Surg 2007; 5 (2): 114–9.
18. Kakkar W, Balibrea JL, Martinez-Gonzalez J, Prandoni P. Extended prophylaxis with bemiparin for the prevention of venous thromboembolism after abdominal or pelvic surgery for cancer: the CANBE- SURE randomized study. J Thromb Haemost 2010; 8 (6): 1223–9.
19. Kakkar W, Gebska M, Kadziola Z et al. Lowmolecular weight heparin in the acute and long-term treatment of deep-vein-thrombosis. Thromb Haemost 2003; 89: 674–80.
20. Santamaria A, Juarez S, Reche A et al. Low-molecular-weight heparin, bemiparin, in the outpatient treatment and secondary prophylaxis of venous thromboembolism in standard clinical practice: the ESFERA study. Int J Clin Pract 2006; 60 (5): 518–25.
21. Lecumberri R, Rosario E, Pacho J, Rocha E. Fixed-dose low-molecular-weight heparin, bemiparin, in the long-term treatment of venous thromboembolism in patients with transient risk factors in standard clinical practice: the FLEBUS study. J Thromb Haemost 2006; 4: 2504–8.
22. Constans M, Santamaria A, Mateo J et al. Low-molecular-weight heparin as bridging therapy during interruption of oral anticoagulation in patients undergoing colonoscopy or gastroscopy. Int J Clin Pract 2007; 61: 212–7.
Авторы
М.Н.Кудыкин
Кафедра инновационной хирургии ГБОУ ВПО НижГМА Минздравсоцразвития РФ