Описано клиническое наблюдение больной целиакией, 23 лет, с тяжелой формой остеопороза, сопровождавшегося атравматичными переломами костей, хромотой, поздним началом менструаций и патологией беременностей. Подчеркивается, что только вовремя установленный диагноз целиакии и своевременно назначенное лечение дают возможность избежать тяжелых осложнений.
A clinical observation of a patient with celiac disease, aged 23, with severe form of osteoporosis, accompanied by atraumatic fractures bones, lameness, late onset of menstruation and pathology of pregnancy is described. It is emphasized that only a timely diagnosis celiac disease and timely prescribed treatment make it possible to avoid severe complications.
1. Парфенов А.И., Быкова С.В., Сабельникова Е.А., Крумс Л.М. и др. Российский консенсус по диагностике и лечению целиакии у детей и взрослых. Терапевтический архив. 2017;89(3)94-107 [Parfenov AI, Bykova SV, Sabelnikova EA, Krums LM, et al. The russian consensus on diagnosis and treatment of coeliac disease in children and adults. Terapevticheskiy Arkhiv. 2017;89(3)94-107 (In Russ.)]. doi: 10.17116/terarkh201789394-107
2. Nadhem ON, Azeez G, Smalligan RD, et al. Review and practice guidelines for celiac disease in 2014. Postgrad Med. 2015;127:259-265. doi: 10.1080/00325481.2015.1015926
3. Catassi C, Gatti S, Lionetti E. World perspective and celiac disease epidemiology. Dig Dis. 2015;33:141-146. doi: 10.1159/000369518
4. Casella G, Orfanotti G, Giacomantonio L, Bella CD, Crisafulli V, Villanacci V, Baldini V, Bassotti G. Celiac disease and obstetrical-gynecological contribution. Gastroenterol Hepatol Bed Bench. 2016 Fall;9(4):241-249.
5. Karaca N, Yilmaz R, Aktun LH, et al. Is there any relationship between unrecognized Celiac disease and unexplained infertile couples? Turk J Gastroenterol. 2015;26:484-486. doi: 10.12659/MSM.909033
6. Cakmak E, Karakus S, Demirpence O, Coskun BD. Ovarian Reserve Assessment in Celiac Patients of Reproductive Age. Med Sci Monit: Int Med J Exper Clin Res. 2018;24:1152-1157.
7. De Re V, Magris R, Cannizzaro R. New insights into the pathogenesis of celiac disease. Front Med (Lausanne). 2017;31:137. doi: 10.3389/fmed.2017.00137
8. Fouda MA. Celiac disease-related osteopathy among Saudi celiac patients: Are we adherent to recommendations? Saudi J Gastroenterol. 2017;23(5):291-295. doi: 10.4103/sjg.SJG_58_17PMCI
9. Larussa T, Suraci E, Nazionale I, Abenavoli L, Imeneo M, Luzza F. Bone mineralization in celiac disease. Gastroenterol Res Pract. 2012;19:8-25. doi: 10.1155/2012/198025
10. Fouda MA, Khan AA, Sultan MS, Rios LP, McAssey K, Armstrong D. Evaluation and management of skeletal health in celiac disease: Position statement. Can J Gastroenterol. 2012;26:819-829. doi: 10.1155/2012/823648
11. Krupa-Kozak U, Dradinska N. Calcium in gluten-free life: Health-related and nutritional implications. Foods. 2016;5(3):51. doi: 10.3390/foods5030051
12. Pantoleoni S, Luchino М, Adriani A, Pellicfno R, Stradella D, Ribaldone DG, et al. Bone mineral densituty at diagnosis of celiac disease and after 1 year of glutebn-free diet. Sci World J. 2014:173082. doi: 10.1155 /2014 /173082
13. Scott EM, Gaywood I, Scott BB. Guidelines for osteoporosis in coeliac disease and inflammatory bowel disease. British Society of Gastroenterology. Gut. 2000;4:61-68.
14. Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA. American College of Gastroenterology. ACG clinical guidelines: Diagnosis and management of celiac disease. Am J Gastroenterol. 2013;108(5):656-676. doi: 10.1038/ajg.2013.79
15. Быкова С.В., Сабельникова Е.А., Парфенов А.И., Гудкова Р.Б, Крумс Л.М., Чикунова Б.З. Репродуктивные расстройства у женщин с целиакией. Эффект этиотропной терапии. Экспериментальная и клиническая гастроэнтерология. 2011;(3):12-18 [Bykova SV, Sabel'nikova EA, Parfenov AI, Gudkova RB, Krums LM, Chikunova BZ. Reproductive disorders in women with celiac disease. Effect of the etiotropic therapy. Eksperimental'naya i Klinicheskaya Gastroenterologiya. 2011;(3):12-18 (In Russ.)].
16. Moleski SM, Lindenmeyer CC, Velosri JJ, Miller RS, Kastenberg D, DiMariano AJ. Increased rates of pregnance complications in women with celiac disease. Ann Gastroenterol. 2015;28(2):236-240.
17. Tavakkoli A, DiGiacomo D, Green PH, Lebwohl B. Vitamin D status and concomitant autoimmunity in celiac disease. J Clin Gastroenterol. 2013;47:515-519. doi: 10.1097/MCG.0b013e318266f81b
18. Албулова Е.А., Дроздов В.Н., Парфенов А.И. Минеральная плотность костной ткани у больных целиакией и лечение заболевания. Экспериментальная и клиническая гастроэнтерология. 2011;(3):25-30 [Albulova EA, Drozdov VN, Parfenov AI. Bone mineral density in patients with celiac disease and medical treatment of the disorder. Eksperimental'naya i Klinicheskaya Gastroenterologiya. 2011;(3):25-30 (In Russ.)].
19. Krupa-Kozak U, Swiatecka D, Baczek N, Brzoska MM. Inulin and fructooligo-saccharide affect in vitro calcium uptake and absorption from cflcium-enriched gluten-free bread. Food Funct. 2016;7(4):1950-8. doi: 10.1039/cbfo00140h/
20. Krupa-Kozak U, Markiewicz LH, Lamparski G, Juskewicz J. Administration of inulin-suppemented gluten-free diet modified calcium absorption and caecal microbiota in rats in calcium-dependent manner. Nutrients. 2017;9(7):piiE702. pii: E702. doi: 10.3390/nu9070702
21. Singh P, Garber JJ. Implementation and adherence to osteoporosis screening guidelines among coeliac disease patients. Dig Liver Dis. 2016;48:1451-1456. doi: 10.1016/j.dld.2016.08.121
22. Liu W, Yang LH, Kong XC, An LK, Wang R. Meta-analysis of osteoporosis: Fracture risks, medication and treatment. Minerva Med. 2015;106:203-214.
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1. [Parfenov AI, Bykova SV, Sabelnikova EA, Krums LM, et al. The russian consensus on diagnosis and treatment of coeliac disease in children and adults. Terapevticheskiy Arkhiv. 2017;89(3)94-107 (In Russ.)]. doi: 10.17116/terarkh201789394-107
2. Nadhem ON, Azeez G, Smalligan RD, et al. Review and practice guidelines for celiac disease in 2014. Postgrad Med. 2015;127:259-265. doi: 10.1080/00325481.2015.1015926
3. Catassi C, Gatti S, Lionetti E. World perspective and celiac disease epidemiology. Dig Dis. 2015;33:141-146. doi: 10.1159/000369518
4. Casella G, Orfanotti G, Giacomantonio L, Bella CD, Crisafulli V, Villanacci V, Baldini V, Bassotti G. Celiac disease and obstetrical-gynecological contribution. Gastroenterol Hepatol Bed Bench. 2016 Fall;9(4):241-249.
5. Karaca N, Yilmaz R, Aktun LH, et al. Is there any relationship between unrecognized Celiac disease and unexplained infertile couples? Turk J Gastroenterol. 2015;26:484-486. doi: 10.12659/MSM.909033
6. Cakmak E, Karakus S, Demirpence O, Coskun BD. Ovarian Reserve Assessment in Celiac Patients of Reproductive Age. Med Sci Monit: Int Med J Exper Clin Res. 2018;24:1152-1157.
7. De Re V, Magris R, Cannizzaro R. New insights into the pathogenesis of celiac disease. Front Med (Lausanne). 2017;31:137. doi: 10.3389/fmed.2017.00137
8. Fouda MA. Celiac disease-related osteopathy among Saudi celiac patients: Are we adherent to recommendations? Saudi J Gastroenterol. 2017;23(5):291-295. doi: 10.4103/sjg.SJG_58_17PMCI
9. Larussa T, Suraci E, Nazionale I, Abenavoli L, Imeneo M, Luzza F. Bone mineralization in celiac disease. Gastroenterol Res Pract. 2012;19:8-25. doi: 10.1155/2012/198025
10. Fouda MA, Khan AA, Sultan MS, Rios LP, McAssey K, Armstrong D. Evaluation and management of skeletal health in celiac disease: Position statement. Can J Gastroenterol. 2012;26:819-829. doi: 10.1155/2012/823648
11. Krupa-Kozak U, Dradinska N. Calcium in gluten-free life: Health-related and nutritional implications. Foods. 2016;5(3):51. doi: 10.3390/foods5030051
12. Pantoleoni S, Luchino М, Adriani A, Pellicfno R, Stradella D, Ribaldone DG, et al. Bone mineral densituty at diagnosis of celiac disease and after 1 year of glutebn-free diet. Sci World J. 2014:173082. doi: 10.1155 /2014 /173082
13. Scott EM, Gaywood I, Scott BB. Guidelines for osteoporosis in coeliac disease and inflammatory bowel disease. British Society of Gastroenterology. Gut. 2000;4:61-68.
14. Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA. American College of Gastroenterology. ACG clinical guidelines: Diagnosis and management of celiac disease. Am J Gastroenterol. 2013;108(5):656-676. doi: 10.1038/ajg.2013.79
15. [Bykova SV, Sabel'nikova EA, Parfenov AI, Gudkova RB, Krums LM, Chikunova BZ. Reproductive disorders in women with celiac disease. Effect of the etiotropic therapy. Eksperimental'naya i Klinicheskaya Gastroenterologiya. 2011;(3):12-18 (In Russ.)].
16. Moleski SM, Lindenmeyer CC, Velosri JJ, Miller RS, Kastenberg D, DiMariano AJ. Increased rates of pregnance complications in women with celiac disease. Ann Gastroenterol. 2015;28(2):236-240.
17. Tavakkoli A, DiGiacomo D, Green PH, Lebwohl B. Vitamin D status and concomitant autoimmunity in celiac disease. J Clin Gastroenterol. 2013;47:515-519. doi: 10.1097/MCG.0b013e318266f81b
18. [Albulova EA, Drozdov VN, Parfenov AI. Bone mineral density in patients with celiac disease and medical treatment of the disorder. Eksperimental'naya i Klinicheskaya Gastroenterologiya. 2011;(3):25-30 (In Russ.)].
19. Krupa-Kozak U, Swiatecka D, Baczek N, Brzoska MM. Inulin and fructooligo-saccharide affect in vitro calcium uptake and absorption from cflcium-enriched gluten-free bread. Food Funct. 2016;7(4):1950-8. doi: 10.1039/cbfo00140h/
20. Krupa-Kozak U, Markiewicz LH, Lamparski G, Juskewicz J. Administration of inulin-suppemented gluten-free diet modified calcium absorption and caecal microbiota in rats in calcium-dependent manner. Nutrients. 2017;9(7):piiE702. pii: E702. doi: 10.3390/nu9070702
21. Singh P, Garber JJ. Implementation and adherence to osteoporosis screening guidelines among coeliac disease patients. Dig Liver Dis. 2016;48:1451-1456. doi: 10.1016/j.dld.2016.08.121
22. Liu W, Yang LH, Kong XC, An LK, Wang R. Meta-analysis of osteoporosis: Fracture risks, medication and treatment. Minerva Med. 2015;106:203-214.